John Zhang, MD, MSc, PhD
Board Eligible Reproductive Endocrinologist and Infertility Specialist
Board Certified in Obstetrics and Gynecology from The American Board of Obstetrics and Gynecology
Doctor Zhang is the Founder/CEO of New Hope Fertility Center in New York City where he has served as the Medical Director since opening in 2004 and oversaw the expanding fertility network internationally to China, Russia, and Mexico.
A true pioneer in the area of minimally invasive (Natural Cycle and Mini-IVF™) fertility care, Dr. John Zhang is an active researcher and medical technology developer. He has been behind several notable achievements in the area of assisted reproductive technology (ART), including the birth of a child by a 49 year-old using her own eggs, helping to restore a young woman’s fertility through a recent ovarian tissue transplant surgery in February of 2012, and being named one of New York’s Top Doctors.
Dr. Zhang completed his medical degree at the Zhejiang University School of Medicine, and subsequently received his Master’s Degree at Birmingham University in the UK. In 1991, Dr. Zhang earned his Ph.D. in In-Vitro Fertilization (IVF), and, after studying and researching the biology of mammalian reproduction and human embryology for nearly ten years, became the first Fellow in the Division of Reproductive Endocrinology and Infertility of New York University’s School of Medicine in 2001.
When it comes to conceiving a baby, Dr. Zhang’s experience successfully resolving fertility issues has made him a leading fertility doctor, both within the United States and internationally. As a renowned innovator in the modern approach to reproductive medicine, he has established some of today’s most groundbreaking infertility solutions, providing help to countless women and couples. Mini-IVF™ allows women who struggle to conceive, an opportunity to reproduce without the invasiveness and physical stress that often accompanies other forms of treatment for fertility. Dr. Zhang commits his visionary approach to the continued progress in the field of reproductive medicine through ongoing research aimed at advancing the field. His ultimate goal is to develop fertility help in ways that are much easier and much less invasive than ever before. From preparing for IVF all the way through successful treatment completion, Dr. Zhang actively oversees his patients’ process and is proud of the achievements heralded by New Hope Fertility Center.
Today, Dr. Zhang continues his research in non-embryonic stem cell research, long-term cryopreservation of oocytes, and oocyte (human egg cell) reconstruction by nuclear transfer. He is currently one of a handful of Reproductive endocrinologists in the United States to hold a Ph.D. in embryology while also being certified as a High Complexity Lab Director.
Keep up with the latest from Dr. Zhang on his blog where he talks about trending topics in the field of Assisted Reproductive Technologies and IVF.
Dr. Zhang speaks English and Chinese.
Message from Dr. John Zhang
“Every woman is unique and therefore customized treatments will give each couple the highest chance of success–a more tailored approach in combination with the latest IVF technology will give you the family you hope for.””
AWARDS & SPECIAL RECOGNITION
- 1989 – 1990 British Medical Research Council research Grant
- 1993 – 1997 China-Cornell Fellowship sponsored by Rockefeller Foundation, USA
- 1997 Winner of the General Prize Paper, the American Society of Reproductive Medicine Annual Meeting; title: In vitro maturation of human preovulatory oocytes following germinal vesicle transfer
- 1997 Winner of the first place poster, the American Society of Reproductive Medicine
Annual Meeting, 1997; title: Electrical activation and in vitro development of
Human oocytes which failed fertilization following intracytoplasmic sperm injection
- 2001 Winner of the best resident research project, Department of OB/Gyn, New York University Medical Center
- 2002 – 2004 ASRM/Organon Research Award to study on “Mitochondrial DNA segregations following nuclear transfer in mouse oocytes”; $50,000 for two years
- TOP 10 of New York
- 2013 Resolve Hope Award for Achievement
- Top Fertility Clinic 2015-2017
- “Nature’s Ten- Ten people that mattered in 2016”
- Busiest IVF Clinics- Forbes, 2016
- 2016 Foreign Policy- Global Thinkers Award Nominee
Zhang, J.J., Boyle, M. and Allen, W.R. (1989)
Recent studies on in vitro maturation and fertilization of equine oocytes. Equine Vet. J., Supple. 8, 101-104
Adghe, A. J-H., Zhang,J.J., Cuthber, J. and Obhria, M. (1989)
Effects on human sperm motility of antisperm antibody: a study using timed exposure photomicrography. Inter. J. Andro. 12, 281-285.
Zhang, J., Boyle, M.S., Smith, C.A., and Moore, H.D. (1990)
Acrosome reaction of stallion spermatozoa evaluated with monoclonal antibody and zona-free hamster eggs. Mol Reprod Dev, 27, 152-158.
Zhang, J.J., Ricketts, W.S. and Tanner, SJ. (1990)
Antisperm antibodies in the semen of a stallion following testicular trauma. Equine Vet. J.
Zhang, J.J., Muzs, L.Z., and Boyle, M.S. (1990)
In vitro fertilization on or horse follicular oocytes matured in vitro. Mol Reprod Dev, 26 361-385.
Zhang, J.J., Muzs, L.Z, and Boyle, M.S. (1991)
Variations in structural and functional changes of stallion spermatozoa in response to calcium ionophore A23187. J. Reprod. Fert, 44,199-205.
Zhang, J.J., Liu, J., Tchabo, J.G., Yang, X., and DiMattina, M. (1994)
Zona-opening of hamster oocytes: a comparative study using macro- and micro-manipulation methods. Hum Reprod 9, 137-140.
Zhang, J., Liu, J., Xu, K.P., Liu, B., and Dimattina, M. (1995)
Extracorporeal development and ultrarapid freezing of human fetal ova .J Assist Reprod12, 361-368.
Zhang, J., Blaszczyk, A., Grifo, J., Li, L., Licciardi, F., Noyes, N., and Krey, L (1997).
Reconstruction of human MII oocytes by partial cytoplasmic substitution. Fertil Steril 68, S154.
Zhang, J., Wang, C.W., Gilfo, J., Adler, A., and Krey, L. (1999)
In vitro maturation of human preovulatory oocytes following reconstruction by germinal vesicle transfer. Fertil Steril 71, 726-731.
Zhang, J., Wang, C.W., Blaszcyzk, Anna., Grifo, J.A., Ozil, Jean., Haberman, Elisa., Adler, Alexis., and Krey, L.C (1999).
Electrical activation and in vitro development of human oocytes that fail to fertilize after intracytoplasmic sperm injection. Fertil Steril 72, 509-512.
Liu, H., Wang, C.W., Grifo, J.A., Krey, L.C., and Zhang, J. (1999)
Reconstruction of mouse oocytes by germinal vesicle transfer: maturity of host oocyte cytoplasm determines meiosis. Hum Reprod14, 2357-2361.
Liu, H., Zhang, J., Krey, L.C., and Grifo, J. A. (2000)
In-vitro development of mouse zygotes following reconstruction by sequential transfer of germinal vesicles and haploid pronuclei. Hum Reprod 15, 1997-2001.
Krey, L., Liu, H., Zhang, J., and Grifo J. (2001)
Fertility and maternal age strategies to improve pregnancy outcome. Ann N V Acad Sci
Liu, H., Krey, L.C., Zhang, J., and Grifo, J.A. (2001)
Ooplasmic influence on nuclear function during the metaphase Il-interphase transition in mouse oocytes. Biol Reprod, 65, 1794-1799.
Moffa, F., Conioglio, F., Krey, L.C., Grifo, J.A., Revelli, A., Massobrio, M., and Zhang, J. (2002)
Germinal vesicle transfer between fresh and cryopreserved immature mouse oocytes. Hum Reprod, 17, 178-183.
Liang, X.Y., Shu, Y.M., Zhuang, G.L., Zhou, C.Q., Zhang, M.F., and Zhang, J.J. (2002).
The priming FSH of women with PCOS to the in vitro maturation procedure and the outcome. Fertil Steril 78, S227.
Liu, H., Krey, L.C., Zhang, J., Chang, H., and Grifo, J. (2002)
Germinal vesicle xeno-transfer between mouse and human oocytes: A model to study ooplasmic influences on meiotic division. Fertil Steril, 78, S77.
Zhang, J., Shu, Y.M., Kret, L.C., Liu, H., Zhuang, G.L., and Grifo, J. (2002).
In vitro development of human triploid zygotes reconstructed by pronuclear transfer.
Fertil Steril 785, 180-181.
Liu, H., Chang, H.C., Zhang, J., Grifo, J., and Krey, L.C. (2003)
Metaphase II nuclei generated by germinal vesicle transfer in mouse oocytes support embryonic development to term. Hum Reprod, 18, 1903-1907.
Zhang, J., Zhuang, G., Zeng, Y., Acosta, C., Shu, Y., and Grifo, J. (2003)
Pregnancy derived from human nuclear transfer. Fertil Steril 80, 56.
Xu, Y., Krey, L., Grifo, J., and Zhang, J. (2003)
DNA methylation patterns in mouse and human zygotes. Fertil Steril 80, 80.
Chang, H.C., Liu, H., Zhang, J., Grifo, J., and Krey, L.C. (2004)
Ooplasmic factors are responsible for the developmental defects observed when immature cumulus-enclosed mouse oocytes are denuded prior to maturation. Fertil Steril 82, S10.
Xu, Y., Zhang, J.J., Grifo, A.J., and Krey, L.C. (2005)
DNA methylation patterns in human tripronucleate zygotes
Mol. Hum. Reprod, 11, 167 – 171.
Zhang, J., Grifo, J., and Del Priore, G. (2005)
Gestational carrier pregnancy with oocytes obtained during surgery for stage IIIc ovarian cancer after controlled ovarian stimulation. Fertil Steril 83, 1547.
Matsuura, T., Kaijima, H., Kato, O., and Zhang, J. (2005)
Serum β-hCG Values as a Reliable Pregnancy Marker After Vitrified-Thawed Single Blastocyst Transfer. Fertil Steril 84, S426.
Priore, G.D., Zhang, J.J., Diflo, T., Silber, S., and Smith, J.R. (2005)
Ovary and Uterine Transplant: A Feasible Rat Model. Fertil Steril 84, S58.
Zhang, J., Zhan, Q., Okimura, T., Kato, K, Silber, S., and Kato, O. (2005)
Comparison of blastocyst formation between standard and clomiphene citrate (CC) stimulated in vitro fertilization (IVF) cycles. Fertil Steril, 84, 311-312.
Zhang, J., Chavez-Badiola,, A., Peng, W., Chang, L., and Ruvalcaba-Castellon, L.A. (2008)
Soft ovarian stimulation IVF (Mini–IVF) vs conventional IVF: an economic perspective. Fertil Steril, 90, S213.
Chavez-Badiola, A., Ruvalcaba-Castellon, L.A., Zhang, J., and Garcia-Amador, M.I. (2008)
Technique safety: oocyte vitrification. Live-births long-term follow-up. Fertil and Steril 90, S205.
Zhang, J., Chavez-Badiola, A., Ruvalcaba-Castellon, L.A., Peng, W., Chang, L., and Silber, J. (2008)
Successful pregnancies through in-vitro fertilization following ovarian tissue transplantation. Fertil and Steril, 90, S81.
Oktay, K., Çil,A.P., and Zhang, J. (2010)
Who is the best candidate for oocyte cryopreservation research? Fertil and Steril 93, 13-15.
Zhang, J., Chang, L., Sone, Y., and Silber, S. (2010)
Minimal ovarian stimulation (Mini-IVF) for IVF utilizing vitrification, and frozen cryopreserved embryo transfer. Reproductive BioMedicine Online 21.
Shu Y, Peng W, and Zhang J. (2010)
Pregnancy and live birth following the transfer of vitrified–warmed blastocysts derived from zona- and corona-cell-free oocytes Reproductive BioMedicine Online 21.
Peng W, Zhang J, Shu Y. (2011)
Live birth after transfer of a twice-vitrified warmed blastocyst that had undergone trophectoderm biopsy. Reprod Biomed Online. 22, 299-302.
Nejat EJ, Luk J, Zhang J. (2014)
How many eggs should I freeze? Fertil Steril. 102:e3.
Zhang J. (2015)
Revisiting germinal vesicle transfer as a treatment for aneuploidy in infertile women with diminished ovarian reserve. J Assist Reprod Genet. 32, 313-7.
Zhang JJ, Feret M, Chang L, Yang M, Merhi Z. (2015)
Obesity adversely impacts the number and maturity of oocytes in conventional IVF not in minimal stimulation IVF. Gynecol Endocrinol. Apr 9:1-5.
Zhang J, Liu H. (2015)
Cytoplasm replacement following germinal vesicle transfer restores meiotic maturation and spindle assembly in meiotically arrested oocytes. Reprod Biomed Online. Apr 16.
Zhang JJ, Merhi Z, Yang M, Bodri D, Chavez-Badiola A, Repping S, van Wely
Minimal Stimulation IVF versus Conventional IVF: A Randomized Controlled Trial. American Journal of Obstetrics and Gynecology. doi: 10.1016/j.ajog.2015.08.009.
Pertynska-Marczewska M, Diamanti-Kandarakis E, Zhang J, Merhi Z. (2015)
Advanced Glycation End Products: A Link between Metabolic and Endothelial Dysfunction in Polycystic Ovary Syndrome? Metabolism. 2015
Zhang J, Merhi Z. (2016)
Could Advanced Glycation End Products Explain the Poor Response to Controlled Ovarian Hyperstimulation in Obese Women? Journal of Endocrinology and Diabetes.
Zhang J, Zhuang G, Yong Z, Grifo J, Acosta C, Shu Y, Liu H. (2016)
Pregnancy Derived from Human Zygote Pronuclear Transfer in a Patient who had Arrested Embryos After IVF. Reproductive Biomedicine Online. 2016.